Personal information

Email：yangjg@pku.edu.cn

Office Address：Room 536, Integrated Science Research Building, Peking University, Beijing, China

Lab Address：Rooms 537 - 543, Integrated Science Research Building, Peking University, Beijing, China

The research field：Microbiology, Synthetic biology, Nitrogen fixation

Biography

Dr Jianguo Yang is an assistant professor in the School of Advanced Agricultural Sciences, the Chief Scientist of National key research and development program for young scientist, and the Bo Ya Young Scientist at Peking University. Jianguo got his B.S. degree from Xiamen University in 2010 and got his Ph.D. degree from Peking university in 2015. After four years postdoctoral training, Jianguo joined the School of Advanced Agricultural Sciences, Peking University and set up his own lab group. His research interests focus on nitrogen fixation and plant nitrogen use efficiency. He has published several papers on famous international journals, including PNAS (5 papers), Cell, Science Advances, and Open Biology etc.

EDUCATION

2006-2010   B.S., School of Life Sciences, Xiamen University, Xiamen, China

2010-2015   Ph.D., School of life sciences, Peking University, Beijing, China

Professional Experience

2015-2019        Postdoctoral researcher, School of Life Sciences, Peking University, Beijing, China

2019-Present   Principal investigator, Assistant professor, School of Advanced Agricultural Sciences, Peking University, Beijing, China

Research Interests

We focus on solving nitrogen fertilizer problems in agricultural by using synthetic biology approaches: 1）Re-constitution of complex biological systems (mainly nitrogen fixation systems) for heterologous expression; 2）Engineering of new rhizosphere microorganisms with higher nitrogen fixation and ammonia secretion abilities; 3）Creation of eukaryotic cells (e.g. yeast cell and plant cell) with self-nitrogen fixation abilities; 4）Enhancing the nitrogen use efficiency in crops with rational designs.

Representative Peer-Reviewed Publications (^#,Co-first author; ^*, Corresponding author)

1. Jianguo Yang^#,*, Nan Xiang^#, Yiheng Liu, Chenyue Guo, Chenyu Li, Hui Li, Shuyi Cai, Ray Dixon^*, Yi-Ping Wang^*. (2023) Organelle-dependent polyprotein designs enable stoichiometric expression of nitrogen fixation components targeted to mitochondria. PNAS. Accepted.

2. Nan Xiang, Chenyue Guo, Jiwei Liu, Hao Xu, Ray Dixon^*, Jianguo Yang^*, Yi-Ping Wang^*. (2020) Using synthetic biology to overcome barriers to stable expression of nitrogenase in eukaryotic organelles. PNAS. 117(28): 16537-16545.

3. Jianguo Yang^#, Xiaqing Xie^#, Nan Xiang, Zhe-Xian Tian, Ray Dixon^*, and Yi-Ping Wang^*. (2018) Polyprotein strategy for stoichiometric assembly of nitrogen fixation components for synthetic biology. PNAS. 115 (36): E8509-E8517. [From the cover and highlighted with commentary by Stefan Burén, Gema López-Torrejón, and Luis M. Rubio. (2018) Extreme bioengineering to meet the nitrogen challenge. PNAS. 115 (36): 8849-8851]

4. Jianguo Yang^#, Xiaqing Xie^#, Mingxuan Yang, Ray Dixon^*, and Yi-Ping Wang^*. (2017) Modular electron-transport chains from eukaryotic organelles function to support nitrogenase activity. PNAS. 114 (12) E2460-E2465. [From the cover and highlighted with commentary by Emilio Jimenez Vicente and Dennis R. Dean. (2017) Keeping the nitrogen-fixation dream alive. PNAS. 114 (12): 3009-3011]

5. Jianguo Yang, Xiaqing Xie, Xia Wang, Ray Dixon^*, and Yi-Ping Wang^*. (2014) Reconstruction and minimal gene requirements for the alternative iron-only nitrogenase in Escherichia coli. PNAS. 111 (35) E3718-E3725.